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Cationic yet natural oligonucleotides. A one-day automated synthesis of any oligonucleotide–oligospermine sequence was developed. Due to charge reversal, these compounds show increased duplex stability with their complementary sequence and are capable of performing strand replacement within a target duplex sequence. Due to a natural nucleic acid backbone, base-pair mismatch discrimination is retained. Diblock cationic oligonucleotides could find applications in diagnostics and therapy.
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Pons et al. (2006) studied this question.
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