Key result
Inhibitors of oxidative phosphorylation and glycolysis severely impaired endothelium-dependent relaxation in rat aortic rings but had much less effect on pulmonary artery relaxation.
Why the study?
Do inhibitors of energy metabolism affect endothelium-dependent relaxation differently in rat pulmonary artery compared to aorta?
Population
Rat aortic and pulmonary artery (PA) rings
Design
Preclinical
Authors
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Metabolic inhibitors should not yet influence clinical vascular management; hypothesis-generating for lower energy dependence in pulmonary versus aortic endothelium.
Do inhibitors of energy metabolism affect endothelium-dependent relaxation differently in rat pulmonary artery compared to aorta?
Oxidative energy production may not be required for receptor-mediated production and/or release of endothelium-derived relaxing factor in pulmonary arterial endothelium, unlike in systemic arteries.
Rodman et al. (1991) studied this question. Inhibitors of oxidative phosphorylation and glycolysis (rotenone, antimycin A, 2-deoxyglucose) vs. Control / comparison between aortic and pulmonary artery rings was evaluated on Endothelium-dependent relaxation to acetylcholine and adenosine diphosphate. Inhibitors of oxidative phosphorylation and glycolysis severely impaired endothelium-dependent relaxation in rat aortic rings but had much less effect on pulmonary artery relaxation.
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