December 1, 1989AJP Heart and Circulatory Physiology

Is nitric oxide the only endothelium-derived relaxing factor in canine femoral veins?

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Population

Rings of the canine femoral vein with and without endothelium

Comparison

Exposure to nitric oxide, acetylcholine, A23187… vs Responses between different pharmacological…

Design

Preclinical

Authors

VMVirginia M. MillerCross-Cutting Cardiology PVPM VanhoutteMayo Clinic

Discussion

Member takes

Implication

Supports mechanistic distinction of venous EDRF from NO; leaves open translation to human vessels.

Structured PICO

Population

Rings of the canine femoral vein with and without endothelium

Intervention

Exposure to nitric oxide, acetylcholine, A23187, and sodium nitroprusside in the presence or absence of inhibitors (superoxide dismutase plus catalase, hemoglobin, methylene blue, LY 83583, ouabain, K+-free solution)

Comparator

Responses between different pharmacological agents and between rings with and without endothelium

Outcome

Measurement of isometric force (relaxations)surrogate

The endothelium-derived relaxing factor in canine systemic veins shares some chemical properties with nitric oxide but differs in its mechanism of action, acting more like sodium nitroprusside.

Cite This Study

Miller et al. (1989) studied this question.

synapsesocial.com/papers/6a828c085bcab2ccdb8d5b50 https://doi.org/10.1152/ajpheart.1989.257.6.h1910

View Full Paper

Ask AI

Bookmark

Is nitric oxide the only endothelium-derived relaxing factor in canine femoral veins?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Is nitric oxide the only endothelium-derived relaxing factor in canine femoral veins?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider