Population
Canine femoral arteries with or without endothelium, and canine coronary artery rings without endothelium
Comparison
Acetylcholine stimulation vs Segments without endothelium; direct NO infusion
Design
Preclinical
Authors
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Questions EDRF as free NO in native arteries; leaves open a labile precursor identity for further study.
EDRF released from native canine femoral artery endothelium cannot be identified as free NO by EPR spectroscopy, suggesting it may be a labile precursor of NO.
Greenberg et al. (1990) studied this question.
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