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December 1, 1987Proceedings of the National Academy of SciencesOpen Access

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

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Key result

Endothelium-derived relaxing factor (EDRF) released from artery and vein possesses identical biological and chemical properties as nitric oxide, including a half-life of 3-5 seconds.

Population

Perfused bovine intrapulmonary artery and vein, and freshly isolated aortic endothelial cells

Comparison

Endothelium-derived relaxing factor released… vs Nitric oxide (NO) delivered by superfusion

Design

Preclinical

Authors

LIL J IgnarroTulane UniversityGBGeorgette M. BugaUniversity of Southern CaliforniaKWK S WoodUniversity of British Columbia

Discussion

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Implication

Supports NO as EDRF in vessels; leaves open translation to human endothelial therapies.

Structured PICO

P
Population
Perfused bovine intrapulmonary artery and vein, and freshly isolated aortic endothelial cells
I
Intervention
Endothelium-derived relaxing factor (EDRF) released from perfused bovine intrapulmonary artery and vein or freshly isolated aortic endothelial cells
C
Comparator
Nitric oxide (NO) delivered by superfusion
O
Outcome
Biological and chemical properties (lability, inactivation/stabilization, cyclic GMP accumulation, reaction with hemoglobin, diazotization of sulfanilic acid)surrogate

This foundational preclinical study demonstrates that endothelium-derived relaxing factor (EDRF) is chemically and biologically identical to nitric oxide (NO).

Cite This Study

Ignarro et al. (1987) studied Vascular smooth muscle relaxation. Endothelium-derived relaxing factor (EDRF) vs. Nitric oxide (NO) was evaluated on Biological and chemical properties (lability, cyclic GMP accumulation, and chemical identification). Endothelium-derived relaxing factor (EDRF) released from artery and vein possesses identical biological and chemical properties as nitric oxide, including a half-life of 3-5 seconds.

synapsesocial.com/papers/6a0ccd359d761985b14a4d92https://doi.org/10.1073/pnas.84.24.9265
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.1986 · 288 citations
  2. 2Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase1974 · 10,403 citations
  3. 3Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells1997 · 226 citations
  4. 4Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.1984 · 44 citations
  5. 5Acetylcholine and Bradykinin Relax Intrapulmonary Arteries by Acting on Endothelial Cells: Role in Lung Vascular Diseases1981 · 224 citations