Population
Cultured bovine endothelial cells seeded onto endothelium-denuded rings of canine coronary artery, and cells…
Comparison
Challenge with dilator drugs in the presence of… vs Pre-seeding state or absence of dilator drugs
Design
Preclinical
Authors
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Characterizes EDRF in cultured cells; extends intact endothelium findings but leaves open human translation.
Cultured endothelial cells release EDRF in response to dilator drugs, demonstrating properties similar to normal endothelium EDRF and distinct from prostacyclin.
Cocks et al. (1985) studied this question.
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