Population
Rabbit aorta and pig coronary artery vessels
Comparison
Acetylcholine, substance P, and calcium… vs Comparison between vessel types and basal release
Design
Preclinical
Authors
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Species- and vessel-specific EDRF responses in animal models caution against clinical extrapolation; leaves open mechanisms in human coronary endothelium.
Different endothelium types release EDRF at widely different rates depending on the agonist used, indicating that the lack of relaxant response to ACh in pig coronary arteries is due to a lack of EDRF release.
Christie et al. (1989) studied this question.
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