Why the study?
Does the presence of endothelium affect the constrictor and relaxant responses to vasoactive agents in isolated rabbit coronary arteries and aortic rings?
Population
Isolated perfused coronary arteries and aortic ring preparations of rabbits
Comparison
Histamine, acetylcholine, phenylephrine, and… vs Preparations with endothelium removed by K-rich…
Design
Preclinical
Authors
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Endothelium modulates coronary reactivity in rabbits; leaves open its role in human vasomotor disease.
Does the presence of endothelium affect the constrictor and relaxant responses to vasoactive agents in isolated rabbit coronary arteries and aortic rings?
The study demonstrates the critical role of endothelium-derived relaxant factor (EDRF) in modulating vascular tone and mediating acetylcholine-induced relaxation in rabbit coronary arteries and aorta.
Griffith et al. (1984) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: