Key result
In isolated rabbit hearts, haemoglobin impaired noradrenaline outflow to 62% of control (P<0.01), while superoxide dismutase augmented it by 15% (P<0.05), and endothelin dose-dependently decreased it.
Population
Isolated rabbit hearts (n=53)
Comparison
Perfusion with haemoglobin, superoxide… vs Control perfusion or mechanical obstruction of…
Design
Preclinical
Authors
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Should not yet inform clinical coronary management; leaves open endothelial modulation of sympathetic release in human hearts.
In isolated rabbit hearts, factors modulating endothelium-derived relaxing factor and endothelin alter coronary flow and parallelly modulate sympathetic noradrenaline release.
Wennmalm et al. (1989) studied Isolated rabbit hearts (n=53). Haemoglobin, Superoxide dismutase, and Endothelin vs. Control was evaluated on Outflow of noradrenaline (NA) and coronary flow. In isolated rabbit hearts, haemoglobin impaired noradrenaline outflow to 62% of control (P<0.01), while superoxide dismutase augmented it by 15% (P<0.05), and endothelin dose-dependently decreased it.
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