Population
rabbit Langendorff hearts
Comparison
Elevated coronary flow and sympathetic nerve… vs Normal coronary flow and resting state
Design
Preclinical
Authors
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Flow-dependent endothelial mediators may modulate noradrenaline outflow in isolated hearts; leaves open in vivo relevance and clinical translation.
An increase in coronary flow in perfused rabbit hearts facilitates the formation of endothelial mediators, which does not affect nerve stimulation-induced release of sympathetic transmitters.
Wennmalm et al. (1991) studied this question.
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