Population
Isolated perfused rabbit hearts, electrically paced
Comparison
Pharmacological modulation with L-NMMA… vs Baseline or alternative pharmacological conditions
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether prostacyclin augmentation counters NO deficiency in coronary reactivity.
In isolated rabbit hearts, prostacyclin contributes to nitric oxide generation, and increasing prostacyclin production can counterbalance impaired nitric oxide generation to attenuate coronary hyperreactivity to endothelin-1.
Berti et al. (1993) studied this question.
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