Key result
EDRF caused significantly greater relaxation and higher peak cyclic GMP levels (2.45 fold vs 1.48 fold) in pig coronary arteries compared to rabbit aortas.
Population
Pre-constricted pig coronary artery (PCA) and rabbit aorta (RA) without endothelium
Comparison
Endothelium-derived relaxing factor released… vs Sodium nitroprusside (NaNP) and 8-bromo-cyclic GMP
Design
Preclinical
Authors
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Links EDRF to cGMP-mediated relaxation in PCA and RA; leaves open in vivo translation and species differences.
Differences in EDRF activity between different artery types can be partially explained by differences in smooth muscle responsiveness to EDRF.
Christie et al. (1988) studied this question. Endothelium-derived relaxing factor (EDRF) vs. Sodium nitroprusside (NaNP) and 8-bromo-cyclic GMP was evaluated on Relaxation responses and cyclic GMP levels. EDRF caused significantly greater relaxation and higher peak cyclic GMP levels (2.45 fold vs 1.48 fold) in pig coronary arteries compared to rabbit aortas.
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