April 1, 1987Circulation Research

Venous and arterial endothelia: different dilator abilities in dog vessels.

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Population

Dog femoral artery and saphenous vein (in vitro 'sandwich' preparation)

Comparison

Endothelium-dependent dilators applied to… vs Different combinations of arterial/venous…

Design

Preclinical

Authors

CSC L SeidelTexas Medical Center JLJonathan LarochelleAllen Institute for Brain Science

Discussion

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Implication

Venous endothelium releases less EDRF than arterial; hypothesis-generating for graft vasoreactivity but should not change practice.

Structured PICO

Population

Dog femoral artery and saphenous vein (in vitro 'sandwich' preparation)

Intervention

Endothelium-dependent dilators (acetylcholine, ionophore A23187, thrombin) applied to 'sandwiched' vessels

Comparator

Different combinations of arterial/venous endothelia and smooth muscle (e.g., de-endothelialized saphenous vein with endothelialized femoral artery vs. de-endothelialized femoral artery with intact saphenous vein)

Outcome

Mechanical response (relaxation/vasodilation) of the de-endothelialized vesselsurrogate

The difference in responsiveness between arteries and veins to endothelium-dependent dilators is primarily due to the lesser ability of venous endothelium to release EDRF rather than smooth muscle insensitivity.

Cite This Study

Seidel et al. (1987) studied this question.

synapsesocial.com/papers/6a724d4653da1ffdb507d22f https://doi.org/10.1161/01.res.60.4.626

View Full Paper

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Venous and arterial endothelia: different dilator abilities in dog vessels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Venous and arterial endothelia: different dilator abilities in dog vessels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider