Key result
Radiofrequency renal denervation with a multi-electrode device reduced average daily SBP/DBP by 12/6 mmHg (p=0.0003/0.0007), providing a greater hypotensive effect than a mono-electrode device.
Why the study?
The study was conducted to evaluate the efficacy and safety of radiofrequency renal denervation using mono-electrode versus multi-electrode devices in patients with uncontrolled arterial hypertension.
Does radiofrequency renal denervation with a multi-electrode device improve blood pressure reduction compared to a mono-electrode device in patients with uncontrolled hypertension?
Observational (n=52)
Does radiofrequency renal denervation with a multi-electrode device improve blood pressure reduction compared to a mono-electrode device in patients with uncontrolled hypertension?
Radiofrequency renal denervation with a multi-electrode device targeting distal branches of renal arteries provides greater blood pressure reduction than a mono-electrode device in patients with uncontrolled hypertension.
Both mono- and multi-electrode RDN lowered office and ambulatory BP at 6 months; leaves open comparative efficacy versus sham in randomized trials.
Aim. To study the efficacy and safety of radiofrequency renal denervation with mono-electrode and multi-electrode devices in patients with uncontrolled arterial hypertension during а 6-month follow-up period. Materials and methods. The study included 52 patients with uncontrolled arterial hypertension, while receiving multicomponent antihypertensive therapy, including diuretic. Patients underwent radiofrequency renal denervation with a mono-electrode (group A; n=27) and multi-electrode devices (group B; n=25). The effectiveness of the procedure was study according to office blood pressure (BP) and ambulatory blood pressure monitoring (ABPM). Results. In group A and B, according to office BP after 6 months, there decreased in SBP/DBP by 32/14 and 30/10 mmHg (р=0.00001/р=0.00001 and p=0.00001/0.0004) respectively. According to ABPM, in group A there was a decrease in the average daily SBP and DBP by 7 and 4 mmHg (р=0.01 and р=0.03) respectively. According to ABPM, after 6 months in group B, there was a decrease in the average daily SBP and DBP by 12 and 6 mmHg (р=0.0003 and р=0.0007) respectively. Conclusions. The results confirm the safety and effectiveness of radiofrequency renal denervation. RDN of the distal branches of the renal arteries leads to a greater hypotensive effect.
No takes yet. Share an insight, caveat, or question.
Agaeva et al. (2020) conducted an observational in uncontrolled arterial hypertension (n=52). Radiofrequency renal denervation with multi-electrode device vs. Radiofrequency renal denervation with mono-electrode device was evaluated on office blood pressure (BP) and ambulatory blood pressure monitoring (ABPM). Radiofrequency renal denervation with a multi-electrode device reduced average daily SBP/DBP by 12/6 mmHg (p=0.0003/0.0007), providing a greater hypotensive effect than a mono-electrode device.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: