July 1, 1989Cardiovascular Research
Platelet hyperreactivity and inefficient spontaneous thrombolysis in patients at high risk from an acute coronary event
Key result
Patients at high risk for acute coronary events exhibited significantly enhanced haemostasis and greatly reduced spontaneous thrombolytic activity compared to matched normal controls.
Why the study?
Do patients at high risk for an acute coronary event exhibit altered haemostasis and spontaneous thrombolysis compared to normal subjects?
Population
113 subjects: 63 patients who had undergone exercise radionuclide ventriculography and 50 matched normal…
Comparison
High risk status for an acute coronary event vs Matched normal subjects
Design
Case-control
Authors
Discussion
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Implication
May identify prothrombotic state as therapeutic target; hypothesis-generating and requires prospective validation before practice change.
Study Design
Type
Case-Control (n=113)
Structured PICO
Do patients at high risk for an acute coronary event exhibit altered haemostasis and spontaneous thrombolysis compared to normal subjects?
P
Population
113 participants, including 63 patients who underwent exercise radionuclide ventriculography (50 at high risk for acute coronary events) and 50 matched normal controls.
E
Exposure
High risk status for an acute coronary event
C
Comparator
Matched normal subjects
O
Outcome
Haemostasis, thrombolysis, and coagulation measured from non-anticoagulated blood samples using a new in vitro techniquesurrogate
Patients at high risk for acute coronary events exhibit platelet hyperreactivity and impaired spontaneous thrombolysis, highlighting a prothrombotic state that may contribute to future events.
Cite This Study
Peters et al. (1989) conducted a case-control in High risk from an acute coronary event (n=113). High risk for acute coronary event vs. Matched normal subjects was evaluated on Haemostasis, thrombolysis and coagulation. Patients at high risk for acute coronary events exhibited significantly enhanced haemostasis and greatly reduced spontaneous thrombolytic activity compared to matched normal controls.