Key result
Formin isoforms encoded by the mouse limb deformity locus are modified by posttranslational phosphorylation at serine and threonine residues and are retained by DNA-cellulose.
Population
Cell lines derived from mice with molecularly defined mutations at the limb deformity locus and wild-type…
Design
Preclinical
Authors
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Characterizes formin modifications in mice; leaves open relevance to human limb development disorders.
The study characterizes formin isoforms encoded by the mouse limb deformity locus, demonstrating they are phosphoproteins capable of DNA binding.
Vogt et al. (1993) studied Mouse limb deformity locus mutations. Formin isoforms encoded by the mouse limb deformity locus are modified by posttranslational phosphorylation at serine and threonine residues and are retained by DNA-cellulose.
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