Key result
Calsequestrin acts as a non-linear calcium buffer and modulator of calcium release channels in the sarcoplasmic reticulum, though cells devoid of it can still release large amounts of calcium.
Population
Skeletal muscle and cardiac muscle models, including mice engineered for calsequestrin ablation
Design
Review
Authors
Loading...
Questions calsequestrin indispensability for SR calcium release; leaves open identification of compensatory buffers in muscle cells.
This review highlights that while calsequestrin is the main Ca2+ binding protein in the sarcoplasmic reticulum, skeletal muscle cells lacking it can still release large amounts of Ca2+, indicating the presence of alternative Ca2+ buffering mechanisms.
Royer et al. (2009) conducted a review in Skeletal muscle excitation-contraction coupling. Calsequestrin was evaluated. Calsequestrin acts as a non-linear calcium buffer and modulator of calcium release channels in the sarcoplasmic reticulum, though cells devoid of it can still release large amounts of calcium.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: