Key result
Depression increases the risk of hypertension incidence, potentially linked through a dysregulation of intracellular Ca2+/cAMP signalling pathways.
Why the study?
Depression is an independent risk factor for hypertension, but the cellular mechanisms linking the two conditions remain to be discussed.
Does depression increase the risk of hypertension incidence through Ca2+/cAMP signalling?
Does depression increase the risk of hypertension incidence through Ca2+/cAMP signalling?
Depression should be considered during the prevention and treatment of hypertension, as it may act as an independent risk factor linked through dysregulation of Ca2+/cAMP signalling.
Links Ca2+ dysregulation to comorbid depression-hypertension; leaves open shared targets for prospective trials.
BACKGROUND: Depression and hypertension are medical problems both with clearly restricted pharmacotherapies, along with a high prevalence around the world. In fact, an intensive discussion in the field is that a dysregulation of the intracellular Ca2+ homeostasis (e.g. excess of intracellular Ca2+) contributes to the pathogenesis of both hypertension and depression. Furthermore, depression rises the risk of hypertension incidence. Indeed, several data support the concept that depression is an independent risk issue for hypertension. CONCLUSION: Then, which are the possible cellular mechanisms involved in this link between depression and hypertension? Considering our previous reports about the Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), in this review I have discussed the virtual involvement of the Ca2+/cAMP signalling in this link (between depression and hypertension). Then, it is important to consider depression into account during the process of prevention, and treatment, of hypertension.
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Leandro Bueno Bergantin (2019) conducted a review in Depression and hypertension. Depression was evaluated. Depression increases the risk of hypertension incidence, potentially linked through a dysregulation of intracellular Ca2+/cAMP signalling pathways.
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