Key result
Bipolar patients in a subsyndromal depressive phase had significantly lower heart rate variability compared to healthy controls, which negatively correlated with symptom severity.
Why the study?
Is heart rate variability reduced in bipolar patients in the subsyndromal depressive phase compared to healthy controls?
Population
92 participants, comprising 33 bipolar patients in the subsyndromal depressive phase and 59 healthy controls.
Design
Case-control
Authors
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Should not yet change monitoring in bipolar depression; hypothesis-generating for HRV as autonomic biomarker.
Case-Control (n=92)
Is heart rate variability reduced in bipolar patients in the subsyndromal depressive phase compared to healthy controls?
Patients with bipolar disorder in a subsyndromal depressive state exhibit reduced heart rate variability that correlates with symptom severity, suggesting underlying autonomic dysfunction.
Lee et al. (2012) conducted a case-control in Bipolar disorder in subsyndromal depressive phase (n=92). Bipolar disorder in subsyndromal depressive phase vs. Healthy controls was evaluated on Heart rate variability parameters (SDNN, pNN50, log TP, VLF). Bipolar patients in a subsyndromal depressive phase had significantly lower heart rate variability compared to healthy controls, which negatively correlated with symptom severity.
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