Key result
Cortical spreading depression induced by K+ in cats caused parenchymal arterioles to initially constrict and then markedly dilate within 1 minute.
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Does not support clinical changes in migraine or stroke care; leaves open CSD effects on human parenchymal arterioles.
A dual illumination technique was used to examine the behavior of parenchymal arterioles of the cortex during cortical spreading depression in six cats. K+ produced a wave-ring spread of optical density changes concentrically from the injection site. At locations where the wave was passing, arterioles first constricted at one or two spots (55+/-43% of control), forming a spindle-shape in the early phase of cortical spreading depression, and then markedly dilated (155+/-57% of control) within 1 min. The dilation started at the constricted spots, propagated bidirectionally and finally resulted in full-length dilation of the arteriole. Although it varied in magnitude and time-course, this arteriolar behavior was observed in all six cats. Despite these changes, no associated downstream tissue microvascular flow changes were discernable.
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Osada et al. (2006) studied cortical spreading depression (n=6). K+ induced cortical spreading depression vs. control (baseline) was evaluated on arteriolar constriction and dilation. Cortical spreading depression induced by K+ in cats caused parenchymal arterioles to initially constrict and then markedly dilate within 1 minute.
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