Key result
A 12-week dietary modification program significantly reduced 2-hour averaged central systolic blood pressure during an oral glucose tolerance test by 8.1 mmHg in overweight and obese men.
Why the study?
Does a 12-week hypocaloric diet intervention improve central systolic blood pressure during OGTT in overweight/obese men?
Does a 12-week hypocaloric diet intervention improve central systolic blood pressure during OGTT in overweight/obese men?
A 12-week hypocaloric diet intervention in overweight/obese men leads to significant weight loss and improvements in insulin resistance.
Answers are grounded in this paper and cite their sources.
Diet-induced weight loss was associated with lower postprandial cSBP; leaves open causal role of insulin resistance in larger controlled studies.
Background: Postprandial regulation of central systolic blood pressure (cSBP) is impaired by obesity-related disorders.The present study aimed to examine the effect of hypocaloric diet intervention on cSBP when performing oral glucose tolerance test (OGTT) in overweight/obese men and explore its mechanism.Methods: Fifteen overweight/obese men (mean Æ SD; age, 52 Æ 10 years; BMI, 29.1 Æ 2.3 kg/ m 2 ) completed a 12-week dietary modification program (group lectures and individual counseling conducted 8 times in 12 weeks, 1680 kcal/day).Before and after the program, body mass, daily intakes of total energy and major macronutrients, serum lipid profiles, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured, and plasma glucose, serum insulin, and cSBP (i.e., radial second systolic pressure) were assessed when fasting and at 60 min and 120 min after 75 g oral glucose loading.Results: The 12-week program led to successful weight loss (À10.1 kg or À12.1%) with significant reductions in the daily intakes of total energy and major macronutrients.Consequently, low-density lipoprotein cholesterol, triglycerides, HOMA-IR (2.1 Æ 1.3 to 0.8 Æ 0.3, p < 0.01), and glucose and insulin during OGTT were substantially decreased after 12 weeks.The diet
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Yoshikawa et al. (2017) studied Overweight and obesity (n=15). Dietary modification program vs. Baseline was evaluated on 2-h averaged central systolic blood pressure (cSBP) during oral glucose tolerance test (MD -8.1 mmHg, 95% CI -13.2 to -3.1, p=<0.01). A 12-week dietary modification program significantly reduced 2-hour averaged central systolic blood pressure during an oral glucose tolerance test by 8.1 mmHg in overweight and obese men.
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