Key result
Equivalent weight loss through a 4-month hypocaloric diet produced comparable reductions in muscle sympathetic nerve activity and whole-body norepinephrine spillover in obese subjects regardless of baseline glucose tolerance.
Why the study?
Does baseline metabolic status influence the degree of sympathoinhibition attained following equivalent dietary weight loss in obese subjects?
Population
54 un-medicated obese individuals, categorized as normal glucose tolerant, impaired glucose tolerant, and…
Design
Cohort
Follow-up
4 months
Authors
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Baseline metabolic status may modulate sympathoinhibition after weight loss; leaves open personalized strategies pending prospective trials.
Cohort (n=54)
No
Does baseline metabolic status influence the degree of sympathoinhibition attained following equivalent dietary weight loss in obese subjects?
p-value: p=<0.001
Equivalent weight loss through a hypocaloric diet yields similar reductions in sympathetic nervous system activity in obese subjects regardless of baseline glucose tolerance, driven primarily by improvements in hyperinsulinemia and hyperlipidemia.
Straznicky et al. (2016) conducted a cohort in Obesity with Normal Glucose Tolerance, Impaired Glucose Tolerance, or Type 2 Diabetes (n=54). Hypocaloric diet vs. Baseline (before-after comparison across 3 glucose tolerance groups) was evaluated on Change in muscle sympathetic nerve activity (MSNA) and whole-body norepinephrine spillover rate (p=<0.001). Equivalent weight loss through a 4-month hypocaloric diet produced comparable reductions in muscle sympathetic nerve activity and whole-body norepinephrine spillover in obese subjects regardless of baseline glucose tolerance.
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