What does this research mean for the field?

In obese normotensive subjects, body weight reduction via a hypocaloric diet significantly decreases sympathetic nerve activity and improves baroreflex sensitivity and insulin sensitivity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to determine if body weight reduction can reverse sympathetic nerve activity and baroreflex impairment in obese normotensive individuals.

May 26, 1998CirculationOpen Access

Body Weight Reduction, Sympathetic Nerve Traffic, and Arterial Baroreflex in Obese Normotensive Humans

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Why the study?

Does a hypocaloric diet reduce sympathetic nerve activity and improve arterial baroreflex in obese normotensive humans?

Population

20 obese normotensive subjects, mean age 31.3+/-1.7 years, mean body mass index 37.6+/-0.9 kg/m2

Comparison

16-week hypocaloric diet with normal sodium… vs 16-week observation period without any reduction…

Design

Cohort

Follow-up

16 weeks

Authors

GGGuıdo GrassıGeneral / Preventive / Lipids GSGino SeravalleGeneral Cardiology MCM. ColomboVirginia Commonwealth University

Discussion

Member takes

Implication

Supports dietary weight loss for sympathetic reduction in obese normotensives; leaves open outcome benefits pending randomized trials.

Key Points

This study aims to determine if body weight reduction can reverse sympathetic nerve activity and baroreflex impairment in obese normotensive individuals.
20 obese normotensive subjects participated; 10 underwent a 16-week hypocaloric diet and 10 were observed without caloric reduction.
Measurements included arterial blood pressure, heart rate, sympathetic nerve activity, and plasma norepinephrine levels during baroreceptor stimulation and deactivation.
Data collection methods included Finapres technique, ECG, microneurography, and high-performance liquid chromatography.
Body weight reduction resulted in a decrease in body mass index and significant reductions in muscle sympathetic nerve activity (from 50.0 to 32.9 bursts per 100 heartbeats, P<.01).
Plasma norepinephrine levels dropped significantly from 356.2 to 258.4 pg/mL (P<.05).
There were significant increases in baroreceptor sensitivity for heart rate and muscle sympathetic nerve activity, along with a 60.8% increase in total body glucose uptake (P<.05).

Structured PICO

Does a hypocaloric diet reduce sympathetic nerve activity and improve arterial baroreflex in obese normotensive humans?

Population

20 obese normotensive subjects, mean age 31.3+/-1.7 years, mean body mass index 37.6+/-0.9 kg/m2

Intervention

16-week hypocaloric diet with normal sodium content (4600 to 5000 J and 210 mmol NaCl/d)

Comparator

16-week observation period without any reduction in caloric intake

Outcome

Changes in muscle sympathetic nerve activity and plasma norepinephrine at rest and during baroreceptor stimulation/deactivationsurrogate

Weight reduction via a hypocaloric diet in obese normotensive individuals significantly reduces sympathetic overactivity and improves both baroreflex sensitivity and insulin sensitivity.

Cite This Study

Grassı et al. (1998) studied this question.

synapsesocial.com/papers/6a128d33c031bb6829a6db96 https://doi.org/10.1161/01.cir.97.20.2037

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Body Weight Reduction, Sympathetic Nerve Traffic, and Arterial Baroreflex in Obese Normotensive Humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Body Weight Reduction, Sympathetic Nerve Traffic, and Arterial Baroreflex in Obese Normotensive Humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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