What does this research mean for the field?

Dietary weight loss via a hypocaloric diet with moderate sodium restriction significantly diminishes sympathetic nervous system activity and improves cardiac baroreflex function in individuals with metabolic syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to examine the effects of dietary weight loss on sympathetic nervous system activity and insulin sensitivity in metabolic syndrome subjects.

November 1, 2005The Journal of Clinical Endocrinology & MetabolismOpen Access

Effects of Dietary Weight Loss on Sympathetic Activity and Cardiac Risk Factors Associated with the Metabolic Syndrome

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Why the study?

Does a hypocaloric modified DASH diet reduce sympathetic nervous system activity in subjects with metabolic syndrome?

Key Points

The study aims to examine the effects of dietary weight loss on sympathetic nervous system activity and insulin sensitivity in metabolic syndrome subjects.
Single-sample, repeated measures design study
Twenty-three metabolic syndrome subjects followed a hypocaloric diet for 3 months
Measured sympathetic nerve activity, norepinephrine spillover, and insulin sensitivity.
Body weight decreased by 7% with the diet
Norepinephrine spillover decreased from 877 to 503 ng/min (P=0.005)
Muscle sympathetic nerve activity reduced from 40.6 to 34.6 bursts/min (P=0.01)

Structured PICO

Does a hypocaloric modified DASH diet reduce sympathetic nervous system activity in subjects with metabolic syndrome?

Population

23 subjects with metabolic syndrome, mean age 58 +/- 2 years, BMI 33.3 +/- 0.8 kg/m2

Intervention

Hypocaloric modified Dietary Approaches to Stop Hypertension (DASH) diet (26% fat, 22% protein, and 51% carbohydrate; 100 mmol/d sodium) consumed for 3 months

Outcome

Postganglionic muscle sympathetic nerve activity (microneurography at a peroneal nerve), whole-body plasma norepinephrine spillover rate, spontaneous cardiac baroreflex function, and insulin sensitivitysurrogate

Weight loss via a hypocaloric DASH diet with moderate sodium restriction significantly reduces sympathetic nervous system activity in patients with metabolic syndrome.

Discussion

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Implication

Hypocaloric DASH diet was associated with reduced sympathetic activity in metabolic syndrome; hypothesis-generating, RCTs needed before practice change.

Cite This Study

Straznicky et al. (2005) studied this question.

synapsesocial.com/papers/6a1be135ea84844e355f1c0b https://doi.org/10.1210/jc.2005-0961

Topics

Women and heart disease

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Implication

Hypocaloric DASH diet was associated with reduced sympathetic activity in metabolic syndrome; hypothesis-generating, RCTs needed before practice change.

Effects of Dietary Weight Loss on Sympathetic Activity and Cardiac Risk Factors Associated with the Metabolic Syndrome

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effects of Dietary Weight Loss on Sympathetic Activity and Cardiac Risk Factors Associated with the Metabolic Syndrome

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Topics

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