What question did this study set out to answer?

This research aims to explore how dietary weight loss affects sympathetic nerve activity in individuals with metabolic syndrome.

January 1, 2011Frontiers in PhysiologyOpen Access

Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

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Why the study?

Does a 3-month low calorie diet reduce sympathetic nerve activity in subjects with metabolic syndrome?

Population

14 subjects (9 men, 5 females), mean age 57 ± 2 years, fulfilling ATP III criteria for the metabolic syndrome

Design

Cohort

Follow-up

3 months

Authors

ÉLÉlisabeth LambertUniversité Paris-Sud

Discussion

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Implication

Low-calorie diet weight loss was associated with decreased MSNA in metabolic syndrome; hypothesis-generating, needs randomized confirmation.

Key Points

This research aims to explore how dietary weight loss affects sympathetic nerve activity in individuals with metabolic syndrome.
Fourteen subjects with metabolic syndrome followed a 3-month low-calorie diet.
Muscle sympathetic nerve activity was measured using microneurography before and after the diet.
Metabolic and hemodynamic parameters were assessed to observe changes.
Weight decreased from 96 ± 4 kg to 88 ± 3 kg (P < 0.001).
Systolic and diastolic blood pressure reduced by -12 ± 3 mmHg and -5 ± 2 mmHg, respectively (P < 0.05).
Single-unit sympathetic nerve activity firing rate decreased from 59 ± 10 to 32 ± 4 spikes/100 heartbeats (P < 0.05).

Structured PICO

Does a 3-month low calorie diet reduce sympathetic nerve activity in subjects with metabolic syndrome?

Population

14 subjects (9 men, 5 females), mean age 57 ± 2 years, fulfilling ATP III criteria for the metabolic syndrome

Intervention

3-month low calorie diet

Outcome

Multi-unit and single-unit muscle sympathetic nerve activity (MSNA), metabolic profile, and hemodynamic parameterssurrogate

Diet-induced weight loss in metabolic syndrome significantly reduces sympathetic nerve activity by altering both the rate and firing pattern of active vasoconstrictive fibers.

Cite This Study

Élisabeth Lambert (2011) studied this question.

synapsesocial.com/papers/6a77f7cfd2fa2470761f38cc https://doi.org/10.3389/fphys.2011.00052

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Implication

Low-calorie diet weight loss was associated with decreased MSNA in metabolic syndrome; hypothesis-generating, needs randomized confirmation.

Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Change in sympathetic nerve firing pattern associated with dietary weight loss in the metabolic syndrome

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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