Key result
Naringenin significantly attenuated pressure overload-induced cardiac hypertrophy, interstitial fibrosis, and left ventricular dysfunction in mice compared to vehicle.
Why the study?
Does naringenin attenuate cardiac hypertrophy and improve left ventricular function in a mouse model of pressure overload?
Population
60 male C57BL/6 mice subjected to aortic banding to induce cardiac hypertrophy.
Comparison
Naringenin administered for 7 weeks, beginning 1… vs Vehicle in mice subjected to aortic banding, as…
Design
Preclinical, Randomly distributed to either a sham surgery or AB group, and…
Follow-up
8 weeks post-surgery
Authors
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Naringenin attenuates hypertrophy and fibrosis in pressure-overloaded mice; leaves open clinical translation.
Does naringenin attenuate cardiac hypertrophy and improve left ventricular function in a mouse model of pressure overload?
p-value: p=<0.05
Naringenin attenuates pressure overload-induced cardiac hypertrophy, interstitial fibrosis, and cardiac dysfunction in mice, likely by inhibiting PI3K/Akt, ERK, and JNK signaling pathways.
Zhang et al. (2015) studied Cardiac hypertrophy (n=60). Naringenin vs. Vehicle was evaluated on Cardiac hypertrophy (HW/BW and HW/TL ratios) (p=<0.05). Naringenin significantly attenuated pressure overload-induced cardiac hypertrophy, interstitial fibrosis, and left ventricular dysfunction in mice compared to vehicle.
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