CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood

was observed in controls 24 hours after the iron challenge (Figure 1).In contrast, the transferrin saturation in the patient increased with the iron challenge.We interpret the late reduction of transferrin saturation in the controls as a delayed effect of hepcidin increase.The lack of this response in the patient supports the notion that defective hepcidin regulation played a role in her iron overload.