Key result
Variable impairment of cell-mediated immunity was observed in ten patients with acrodermatitis enteropathica, eight of whom had low plasma zinc levels.
Case Report (n=10)
Patients with acrodermatitis enteropathica demonstrate variable impairment of cell-mediated immunity, which is frequently associated with low plasma zinc levels.
Alerts clinicians to possible immune compromise in acrodermatitis enteropathica; leaves open whether zinc repletion restores cell-mediated immunity.
Acrodermatitis enteropathica (AE) is a rare vesicobullous skin disorder.1 Genealogic data suggest an autosomal recessive mode of inheritance. The onset of symptoms is generally insidious. In breastfed infants, the disorder may be precipitated on weaning to cow's milk. The frequent occurrence of secondary infections, particularly with opportunistic fungi and bacteria, led to the suspicion that AE is associated with immunodeficiency. "Dysgammaglobulinemia" has been reported in one infant2 and defective chemotaxis in another three patients.3 Limited autopsy observations showed atrophic thymus, tonsils, germinal centers, and Peyer patches.2,4 We report variable impairment of cell-mediated immunity in ten patients with AE of whom eight had low plasma zinc levels.
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R. K. Chandra (1980) conducted a case report in Acrodermatitis enteropathica (n=10). Acrodermatitis enteropathica was evaluated on Cell-mediated immunity and plasma zinc levels. Variable impairment of cell-mediated immunity was observed in ten patients with acrodermatitis enteropathica, eight of whom had low plasma zinc levels.
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