Key result
Rapid withdrawal of high-dose corticosteroids during MOPP chemotherapy may activate subclinical radiation injury in the lungs or heart in patients with prior mantle radiation therapy.
Why the study?
Does rapid withdrawal of high-dose corticosteroids activate latent radiation injury of the lungs or heart in patients with Hodgkin's disease previously treated with mantle radiation?
Population
7 patients with Hodgkin's disease who had prior "mantle" radiation therapy and received MOPP chemotherapy
Design
Case_series
Follow-up
A few months to 6 years between radiation and development…
Authors
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Caution against rapid corticosteroid withdrawal after mantle RT; hypothesis-generating for tapering protocols in radiation-exposed survivors.
Case Report (n=7)
Does rapid withdrawal of high-dose corticosteroids activate latent radiation injury of the lungs or heart in patients with Hodgkin's disease previously treated with mantle radiation?
Rapid withdrawal of high-dose corticosteroids in patients with prior mantle radiation may trigger latent radiation-induced heart or lung injury, which responds to reinstitution and slow tapering of corticosteroids.
Castellino et al. (1974) conducted a case report in Hodgkin's disease (n=7). Rapid withdrawal of high-dose corticosteroids was evaluated on Development of radiation pneumonitis or radiation-induced heart disease. Rapid withdrawal of high-dose corticosteroids during MOPP chemotherapy may activate subclinical radiation injury in the lungs or heart in patients with prior mantle radiation therapy.
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