Key result
Administration of 2.5 mg of oral dextroamphetamine prevented severe vasodepressor syncope during repeat head-up tilt table testing in all 3 patients.
Why the study?
Does oral dextroamphetamine prevent severe vasodepressor syncope in patients with a history of tilt-table induced syncope?
Case Report (n=3)
Does oral dextroamphetamine prevent severe vasodepressor syncope in patients with a history of tilt-table induced syncope?
A low dose of oral dextroamphetamine prevented vasodepressor syncope during tilt-table testing in a small series of three susceptible patients.
May prevent tilt-induced vasodepressor syncope; hypothesis-generating from 3-patient case series, needs prospective trials before any practice change.
Three patients with history of documented hypotension, near syncope, or syncope before or after the administration of isoproterenol during head-up tilt table are reported. Severe bradycardia was also noted in one patient. All three patients responded to the administration of 2.5 mg of oral dextroamphetamine 45 minutes prior to a repeat head-up tilt table study. The potent central and peripheral adrenergic agonist pharmacological properties of this drug permitted the prevention of severe vasodepressor syncope in these patients.
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Susmano et al. (1993) conducted a case report in Vasodepressor Syncope (n=3). Dextroamphetamine was evaluated on Prevention of severe vasodepressor syncope during repeat head-up tilt table study. Administration of 2.5 mg of oral dextroamphetamine prevented severe vasodepressor syncope during repeat head-up tilt table testing in all 3 patients.
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