Regiospecific (9-) and regioselective (7-) coupling procedures have been developed with easily prepared guanine derivatives. Acyclovir and 9-(D-pentofuranosyl)guanine nucleosides have been prepared without observed formation of 7-isomers. Guanosine has been functionalized and transformed into a variety of base and/or sugar modified analogues. Potent activity against HIV and a hepadnavirus has been found.
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Zou et al. (1989) studied this question.
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