Key result
Factor V Leiden deficiency produces a hypercoagulable state associated with venous thromboembolism, requiring urgent treatment with heparin and continued home anticoagulation.
Patients with Factor V Leiden presenting with pulmonary embolism require urgent treatment with heparin and continued home anticoagulation.
Supports anticoagulation in Factor V Leiden VTE; leaves open generalizability and optimal duration.
Venous thromboembolism (VTE) is a complication associated with the hypercoaguable state produced in patients with Factor V Leiden deficiency. Clinically, patients can present with pleuritic chest pain, dyspnea, tachycardia, and unilateral leg swelling, warmth, erythema, and pain. Treatment with heparin is urgent, and patients should continue an anticoagulation drug regimen at home.
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Downs et al. (2016) studied this question. Factor V Leiden deficiency produces a hypercoagulable state associated with venous thromboembolism, requiring urgent treatment with heparin and continued home anticoagulation.
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