The affinity of the long arm of the Ychromosome for quinacrine dihydrochloride has been used in a study of size variation in this chromosome. Measurements made on cells from 12 subjects with Y chromosomes of different sizes have clearly indicated that it is variation in the fluorescent area which accounts for the size differences. The nonfluorescent region of the chromosome is apparently stable. The possible significance of these findings is discussed.
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Bobrow et al. (2008) studied this question.