Key result
Among 8,047 participants (530 CV events), all eGFR measures were associated with CV events in those <60 years, but only 24-hour creatinine clearance was associated in those ≥60 years.
Why the study?
Does the association between eGFR and cardiovascular events differ by age and the method of eGFR measurement in an outpatient population?
Cohort (n=8,047)
Does the association between eGFR and cardiovascular events differ by age and the method of eGFR measurement in an outpatient population?
The prognostic value of eGFR for cardiovascular events is age-dependent, being weaker in older adults (≥60 years) across most estimation formulas except 24-hour creatinine clearance.
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eGFR-CV associations weaken after age 60 except for creatinine clearance; hypothesis-generating for age-specific GFR methods in risk prediction.
Velde et al. (2010) conducted a cohort in General population (n=8,047). Estimated GFR (eGFR) measures vs. Different age groups (<60 vs ≥60 years) was evaluated on Cardiovascular events. Among 8,047 participants (530 CV events), all eGFR measures were associated with CV events in those <60 years, but only 24-hour creatinine clearance was associated in those ≥60 years.
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