Key result
Pre-operative BNP and NT-proBNP showed moderate predictive ability for adverse outcomes after cardiac surgery, with AUCs of 0.61 for mortality, 0.61 for post-operative AF, and 0.81 for IABP requirement.
Why the study?
Do pre-operative BNP and NT pro-BNP predict adverse outcomes in patients undergoing cardiac surgery?
Population
4,933 patients from 22 studies (observational or randomized control trials) undergoing cardiac surgery
Design
Meta-analysis
Authors
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May limit routine risk stratification for mortality or AF; confirms moderate utility, strongest for IABP need.
Meta-Analysis (n=4,933)
Do pre-operative BNP and NT pro-BNP predict adverse outcomes in patients undergoing cardiac surgery?
Effect estimate: AUC 0.61 (95% CI 0.51-0.70)
Pre-operative natriuretic peptide levels have moderate predictive ability for adverse outcomes after cardiac surgery, particularly for post-operative IABP requirement.
Litton et al. (2011) conducted a meta-analysis in cardiac surgery (n=4,933). Pre-operative brain natriuretic peptides (BNP and NT-proBNP) was evaluated on mortality (AUC 0.61, 95% CI 0.51-0.70). Pre-operative BNP and NT-proBNP showed moderate predictive ability for adverse outcomes after cardiac surgery, with AUCs of 0.61 for mortality, 0.61 for post-operative AF, and 0.81 for IABP requirement.
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