Key result
The classification of congenital antithrombin III deficiencies remains difficult, as classical definitions are inadequate for variants like antithrombin Oslo and Budapest.
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Highlights the complexity and inadequacy of current classification systems for congenital antithrombin III deficiencies.
In a recent issue of your journal Hultin et al. (1) discussed antithrombin Oslo and reviewed 33 other variants of congenital antithrombin III (AT-III) deficiencies. This paper demonstrates the difficulties of classifying congenital AT-III deficiencies, since now it has turned out, that the "most classical" AT-III deficiency described by Egeberg in L965, ironically, is not "classical" at all, as it has been defined. Their paper clearly shows the inadequacy antithrombin III (Antithrombin III "Budapest") as a cause of a familial thrombophilia.
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G. Sas (1988) conducted a letter in Congenital antithrombin III deficiency. Classification of congenital antithrombin III deficiencies was evaluated. The classification of congenital antithrombin III deficiencies remains difficult, as classical definitions are inadequate for variants like antithrombin Oslo and Budapest.
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