Effect of Drugs on the Agents Causing Infectious Sinusitis of Turkeys and Chronic Respiratory Disease (Air-Sac Infection) of Chickens

THE multiplication of the agent of infectious sinusitis of turkeys was found (Hitchner, 1949) to be inhibited by streptomycin in eggs. Groupé (1949) showed that 0.5 mg. of streptomycin, or 1.0 mg. of aureomycin per egg, significantly delayed death of chicken embryos inoculated with the infectious sinusitis agent. The agent of chronic respiratory disease of chickens was found (Delaplane, 1949) to be sensitive to streptomycin and (VanRoekel, 1951) to be sensitive to aureomycin, terramycin, and Chloromycetin. This report concerns the relative sensitiveness of 3 strains of the agent of infectious sinusitis isolated from turkeys, and 2 strains of the agent of chronic respiratory disease isolated from chickens, to drugs in embryonating eggs. MATERIALS AND METHODS The strains of agents used in these experiments were: The “W” agent of chronic respiratory disease which was recovered from a flock of chickens from Winchester, Virginia; the “S” strain of chronic respiratory disease which . . .