Key result
Fluoxetine ameliorated metabolic, vascular, and inflammatory abnormalities associated with diabetes and chronic stress in rats, whereas imipramine induced no change or worsened some parameters.
Why the study?
Does fluoxetine or imipramine improve metabolic, vascular, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic stress?
Does fluoxetine or imipramine improve metabolic, vascular, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic stress?
Fluoxetine, but not imipramine, improves metabolic, vascular, and inflammatory abnormalities in a rat model of diabetes and chronic stress, suggesting a preference for fluoxetine in managing comorbid depression in diabetic patients.
May favor fluoxetine over imipramine in diabetic stress models; hypothesis-generating for comorbid depression management.
UNLABELLED: Several studies reveal that diabetes doubles the odds of comorbid depression with evidence of a pro-inflammatory state underlying its vascular complications. Indeed, little information is available about vascular effects of antidepressant drugs in diabetes. METHOD: We investigated the effect of chronic administration of fluoxetine "FLU" and imipramine "IMIP" on behavioral, metabolic and vascular abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS). RESULTS: Both diabetes and CRS induced depressive-like behavior which was more prominent in diabetic/depressed rats; this was reversed by chronic treatment with FLU and IMIP in a comparable manner. Diabetic and non-diabetic rats exposed to CRS exhibited abnormalities in glucose homeostasis, lipid profile and vascular function, manifested by decreased endothelium-dependent relaxation, increased systolic blood pressure and histopathological atherosclerotic changes. Vascular and metabolic dysfunctions were associated with significant increase in aortic expression of TLR-4, and pro-inflammatory cytokines (TNF-α and IL-1ß). FLU ameliorated these metabolic, vascular and inflammatory abnormalities, while IMIP induced either no change or even worsening of some parameters. CONCLUSION: FLU has favorable effect over IMIP on metabolic, vascular and inflammatory aberrations associated with DM and CRS in Wistar rats, clarifying the preference of FLU over IMIP in management of comorbid depression in diabetic subjects.
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Habib et al. (2015) studied Diabetes and comorbid depression (chronic restraint stress model) (n=92). Fluoxetine and Imipramine vs. Vehicle was evaluated on Metabolic, vascular, and inflammatory abnormalities (including TLR-4 expression). Fluoxetine ameliorated metabolic, vascular, and inflammatory abnormalities associated with diabetes and chronic stress in rats, whereas imipramine induced no change or worsened some parameters.
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