What question did this study set out to answer?

To review the regulatory roles of the Notch signaling pathway in hematolymphoid cell lineage specification, early differentiation, and mature lymphocyte function.

February 11, 2005Annual Review of Immunology

Regulation of Lymphoid Development, Differentiation, and Function by the Notch Pathway

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Authors

IMIvan MaillardBrigham and Women's Hospital TFTerry FangBiogen (United States)WPWarren S. PearUniversity of Pennsylvania

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Implication

Review reveals extensive regulation of lymphoid differentiation across hematolymphoid cells, highlighting its essential control over immune cell fate.

Key Points

To review the regulatory roles of the Notch signaling pathway in hematolymphoid cell lineage specification, early differentiation, and mature lymphocyte function.
Narrative synthesis of peer-reviewed experimental studies detailing Notch signaling mechanisms across hematopoiesis and lymphoid biology.
Evaluation of findings spanning embryonic hematopoietic stem cell emergence, intrathymic T-cell specification, and peripheral immune responses.
Notch signaling dictates the embryonic generation of hematopoietic stem cells and contributes to their ongoing post-embryonic maintenance.
Activation of the Notch pathway is indispensable for directing common lymphoid progenitors toward the T-cell lineage during early thymopoiesis.
Notch modulates downstream effector differentiation and immune activation in both mature peripheral T cells and B cells.

Cite This Study

Maillard et al. (2005) studied this question.

synapsesocial.com/papers/6a98058c2b5b2a1696e183df https://doi.org/10.1146/annurev.immunol.23.021704.115747

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Implication

Review reveals extensive regulation of lymphoid differentiation across hematolymphoid cells, highlighting its essential control over immune cell fate.

Regulation of Lymphoid Development, Differentiation, and Function by the Notch Pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Regulation of Lymphoid Development, Differentiation, and Function by the Notch Pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

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