Key result
Psoriasis was associated with significantly impaired ventricular repolarization features, including an increased Tp-e/QT ratio (0.25 vs. 0.23, p<0.001) compared to healthy controls.
Why the study?
Do patients with psoriasis have impaired ventricular repolarization features compared to healthy controls?
Cross-Sectional (n=148)
Single-blind
Do patients with psoriasis have impaired ventricular repolarization features compared to healthy controls?
Absolute Event Rate: 0.25% vs 0.23%
p-value: p=<0.001
Patients with psoriasis exhibit impaired ventricular repolarization features, including increased Tp-e interval and Tp-e/QT ratio, which may indicate an increased risk for ventricular arrhythmias.
Psoriasis-linked repolarization changes may warrant arrhythmia vigilance; leaves open prospective outcome validation before practice change.
OBJECTIVE: Psoriasis is a chronic inflammatory disorder, which affects around 1%-3% of the human population worldwide. Cardiovascular events are the leading cause of morbidity and mortality in patients with psoriasis. Some studies have reported that psoriasis is related to increased arrhythmias. The Tp-e interval and Tp-e/QT ratio have been accepted as new markers for the assessment of myocardial repolarization and ventricular arrhythmogenesis. The aim of this study was to assess ventricular repolarization in patients with psoriasis using Tp-e interval and Tp-e/QT ratio. METHODS: The study population consisted of 74 patients with psoriasis and 74 healthy volunteers. The diagnosis of psoriasis was based on a clinical or histopathological examination of all patients. QT interval, corrected QT (QTc), QT dispersion (QTd), Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were measured from the 12-lead electrocardiogram. These parameters were compared between groups. RESULTS: According to the electrocardiographic parameters, QT and QTc intervals and QTd were significantly higher in patients with psoriasis than in control subjects (p<0.001; p<0.001; p=0.014; respectively). The Tp-e interval, corrected Tp-e, and Tp-e/QT ratio were significantly higher in patients with psoriasis than in control subjects [93±13 milliseconds (ms) vs. 98±14 ms, p=0.040; 104±17 ms vs. 111±17 ms, p=0.008; 0.23±0.03 vs. 0.25±0.03, p<0.001; respectively]. Additionally, the CRP value was an independent predictor of an increased Tp-e/QT ratio (ß=0.537, p< 0.001). CONCLUSION: Our study revealed that ventricular repolarization features were impaired in patients with psoriasis. Therefore, these patients should be more closely screened for ventricular arrhythmias.
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Arif Arısoy (2017) conducted a cross-sectional in Psoriasis (n=148). Psoriasis vs. Healthy volunteers was evaluated on Tp-e/QT ratio (p=<0.001). Psoriasis was associated with significantly impaired ventricular repolarization features, including an increased Tp-e/QT ratio (0.25 vs. 0.23, p<0.001) compared to healthy controls.
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