Key result
5/6 nephrectomy increased neurogenic and chemical-induced vascular tone in normotensive rats but decreased it in initially hypertensive rats, particularly in the internal carotid artery.
Why the study?
To test the hypothesis that chronic kidney disease leads to an increase in neurogenic vascular tone in both normal and hypertensive animals.
Does 5/6 nephrectomy alter neurogenic vascular tone in arteries from normotensive and spontaneously hypertensive rats?
Does 5/6 nephrectomy alter neurogenic vascular tone in arteries from normotensive and spontaneously hypertensive rats?
Chronic kidney disease may increase neurogenic and chemical-induced vascular tone in normotensive animals but decrease it in initially hypertensive animals.
Answers are grounded in this paper and cite their sources.
Baseline hypertension may modify CKD effects on vascular tone in rats; leaves open human translation.
The effects of nephrectomy on the electrical field stimulation-evoked changes in tone of Wistar–Kyoto (WKY) and spontaneously hypertensive rat (SHR) superior mesenteric artery (SMA) and internal carotid artery (ICA) segments were studied. The hypothesis that chronic kidney disease (CKD) leads to an increase in neurogenic vascular tone in both normal and hypertensive animals was tested. 5/6 nephrectomy in the rats was used as a model of CKD. Neurogenic constriction of the segments was induced by the electrical field stimulation of the perivascular nerves in the absence and presence of potassium channels blockers (tetraethylammonium, glibenclamide) or methylene blue, a guanylyl-cyclase inhibitor. In the absence of blockers, nephrectomy was found to increase neurogenic contraction only in SMA from WKY. In addition, in SMA, this effect of nephrectomy was manifested in the presence of glibenclamide. In the presence of blockers, the neurogenic response of the SMA from SHR did not depend on nephrectomy, while in ICA from nephrectomized rats under these conditions, neurogenic constriction in WKY and dilatation in SHR was more significant than in control animals. Nephrectomy-related increase in artery constriction in WKY was also evoked by phenylephrine in SMA and tetraethylammonium in ICA, while in SHR, nephrectomy led to a decrease in ICA constriction evoked by phenylephrine and tetraethylammonium. The data obtained suggest that CKD may lead to an increase in neurogenic and chemical-induced vascular tone in normotensive animals and to its decrease in initially hypertensive animals. To the greatest extent, these changes can be expressed in the ICA and are associated with an increase in the activity of potassium channels and guanylyl-cyclase in this artery in CKD in initially normotensive animals and with a decrease in this activity in initially hypertensive animals.
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V. N. Yartsev (2022) studied Chronic kidney disease (CKD) model in normotensive and hypertensive rats. 5/6 nephrectomy vs. Control animals was evaluated on Electrical field stimulation-evoked changes in tone of superior mesenteric artery and internal carotid artery segments. 5/6 nephrectomy increased neurogenic and chemical-induced vascular tone in normotensive rats but decreased it in initially hypertensive rats, particularly in the internal carotid artery.
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