What question did this study set out to answer?

Summarize the role of lysosomal cysteine proteinases and their natural inhibitors in tumor progression and assess their clinical utility in cancer prognosis, diagnosis, and treatment.

November 1, 1998Oncology Reports

Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review).

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Authors

JKJanko KosUniversity of Ljubljana TLTamara T. LahHonda (Japan)

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Implication

Review reveals strong prognostic value of cathepsin and cystatin imbalances in human cancers, highlighting their potential as diagnostic markers and therapeutic targets.

Key Points

Summarize the role of lysosomal cysteine proteinases and their natural inhibitors in tumor progression and assess their clinical utility in cancer prognosis, diagnosis, and treatment.
Reviewed clinical and biological investigations examining cysteine cathepsins and their endogenous inhibitors (cystatins, stefins, kininogens) across human tumor tissues and patient biofluids.
Evaluated molecular expression patterns across various malignancies, including breast, lung, brain, head and neck, ovarian, uterine, melanoma, and colorectal cancers.
Malignant tumors consistently exhibit an imbalance between cathepsins and their endogenous inhibitors, characterized by aberrant enzyme expression, processing, and localization that facilitate tumor invasion and metastasis.
Cathepsin and inhibitor levels in tumor tissue and patient body fluids reliably predict survival duration, providing effective risk stratification for tumor recurrence and mortality across diverse cancer types.

Cite This Study

Kos et al. (1998) studied this question.

synapsesocial.com/papers/6a980d4f60ee10bf83a67db1 https://doi.org/10.3892/or.5.6.1349

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Implication

Review reveals strong prognostic value of cathepsin and cystatin imbalances in human cancers, highlighting their potential as diagnostic markers and therapeutic targets.

Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review).

Discussion

Member takes

Implication

Key Points

Cite This Study

Cysteine proteinases and their endogenous inhibitors: target proteins for prognosis, diagnosis and therapy in cancer (review).

Discussion

Member takes

Implication

Key Points

Cite This Study

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