Key result
The combination of Vitamin E and SMe1EC2 significantly reduced systolic blood pressure (130.96 vs 153.82 mm Hg) and suppressed serious dysrhythmias in rats with diet-induced metabolic syndrome.
Why the study?
Long-lasting disturbances in lipid and glucose metabolism in metabolic syndrome lead to serious cardiovascular diseases, prompting evaluation of the effects of vitamin E alone and combined with SMe1EC2 on metabolic and cardiac function.
Does the combination of vitamin E and SMe1EC2 improve biochemical parameters and reduce reperfusion dysrhythmias in HTG rats fed a high-fat fructose diet?
Does the combination of vitamin E and SMe1EC2 improve biochemical parameters and reduce reperfusion dysrhythmias in HTG rats fed a high-fat fructose diet?
Absolute Event Rate: 130.96% vs 153.82%
p-value: p=<0.01
In a rat model of metabolic syndrome, the combination of vitamin E and SMe1EC2 improved blood pressure and reduced ischemia-reperfusion-induced serious ventricular dysrhythmias.
Premature for clinical use in metabolic syndrome; leaves open further translational research on vitamin E and SMe1EC2.
Long-lasting disturbances in lipid and glucose metabolism present in metabolic syndrome (MetS) lead to serious cardiovascular diseases. The study was aimed to evaluate the effect of natural antioxidant vitamin E (VitE, 100 mg/kg/day, p.o.) on basal biochemical and physiological parameters characterizing MetS and on the changed function of the heart. Furthermore, the possible potentiation of VitE effect by synthetic pyridoindole antioxidant SMe1EC2 (SMe, 15 mg/kg/day, p.o.) was also tested. MetS was induced in hereditary hypertriglyceridemic rats (HTG) by the 5 weeks administration of high-fat fructose diet (HFFD: 1 % cholesterol, 7.5 % pork lard, 10 % fructose). The heart function was tested using Langendorff preparation under constant pressure. The functional parameters of isolated heart, dysrhythmias and evoked fibrillations were evaluated in conditions of ischemia-reperfusion. The HFFD increased body weight gain and serum levels of total cholesterol, low-density lipoproteins and blood glucose. The HFFD significantly increased heart flow and force of contraction, compared to standard diet (SD). During the reperfusion, the HFFD caused the increase of the ventricular premature beats number at the expense of decreasing the duration of serious dysrhythmias (ventricular tachycardias and fibrillations). The addition of VitE, SMe or their combination to the HFFD decreased body weight gain, depressed blood pressure, improved particular biochemical parameters. The combination of VitE and SMe suppressed the occurrence of serious dysrhythmias. Our data indicate that the HFFD-related disturbances led to alterations within pathophysiology in HTG rats. The results showed that a combination of antioxidants might have the potential to amend disorders accompanying MetS.
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Brnoliaková et al. (2023) studied Metabolic syndrome (n=50). Vitamin E and SMe1EC2 vs. High-fat fructose diet alone was evaluated on Systolic blood pressure at 5 weeks (p=<0.01). The combination of Vitamin E and SMe1EC2 significantly reduced systolic blood pressure (130.96 vs 153.82 mm Hg) and suppressed serious dysrhythmias in rats with diet-induced metabolic syndrome.
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