Why the study?
Does midazolam premedication influence the plasma concentrations of bupivacaine and lidocaine after caudal injection in children undergoing surgery?
Does midazolam premedication influence the plasma concentrations of bupivacaine and lidocaine after caudal injection in children undergoing surgery?
Rectal midazolam premedication significantly reduces the systemic exposure (AUC) of lidocaine but not bupivacaine when administered as a caudal block mixture in children.
Rectal midazolam may alter lidocaine dosing considerations in pediatric caudals; extends pharmacokinetic interaction data for regional anesthesia mixtures.
Twenty children undergoing surgery received a caudal block using 1 ml per kg of a mixture of 50% lidocaine (1%) and 50% bupivacaine (0.25%). They were randomly allocated to two groups, one of which received midazolam 0.4 mg/kg rectally as premedication. Midazolam administration resulted in a significantly lower AUC value for lidocaine but did not influence the plasma concentrations of bupivacaine.
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Giaufré et al. (1990) studied this question.
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