Why the study?
What are the plasma bupivacaine concentrations in children following caudal epidural analgesia with 3 mg/kg of bupivacaine 0.25%?
Population
45 children, ages ranging from 4 months to 12 years
Design
Cohort
Follow-up
15 minutes
Authors
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May support safe caudal bupivacaine dosing in children; leaves open need for randomized confirmation of sampling-site effects and toxicity thresholds.
What are the plasma bupivacaine concentrations in children following caudal epidural analgesia with 3 mg/kg of bupivacaine 0.25%?
Caudal epidural analgesia with 3 mg/kg of bupivacaine 0.25% in children produces plasma concentrations safely below projected toxic levels.
Eyres et al. (1983) studied this question.
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