Why the study?
What are the peak plasma concentrations of bupivacaine after axillary block with 2 mg/kg versus 3 mg/kg in children?
Population
41 children receiving axillary brachial plexus block
Comparison
Bupivacaine 3 mg/kg vs Bupivacaine 2 mg/kg
Design
Cohort
Authors
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These subtoxic peaks support cautious dosing in pediatric axillary blocks; leaves open need for randomized safety and efficacy trials.
What are the peak plasma concentrations of bupivacaine after axillary block with 2 mg/kg versus 3 mg/kg in children?
Bupivacaine doses of 2 mg/kg and 3 mg/kg for axillary block in children result in rapid absorption but produce peak plasma concentrations well below toxic thresholds.
Campbell et al. (1986) studied this question.
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