Why the study?
What are the plasma concentrations of bupivacaine in neonates receiving continuous epidural infusion after major abdominal surgery?
Population
13 neonates undergoing major abdominal surgery
Design
Case_series
Follow-up
48 hours
Authors
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May warrant caution with bupivacaine infusions beyond 48 hours in neonates; leaves open questions on accumulation and safety.
What are the plasma concentrations of bupivacaine in neonates receiving continuous epidural infusion after major abdominal surgery?
Continuous epidural infusion of bupivacaine at 0.2 mg/kg/h in neonates appears safe up to 48 hours, but increasing total plasma concentrations raise concerns for longer infusions.
Larsson et al. (1997) studied this question.
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