Key result
Spinal bupivacaine for cesarean section crosses the placenta minimally, yielding umbilical levels of ~20 ng/ml.
Why the study?
What is the disposition and placental transfer of bupivacaine after spinal anesthesia for cesarean section?
Population
6 patients undergoing elective cesarean section
Design
Cohort
Follow-up
up to 36 hours after delivery
Authors
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Low placental transfer supports minimal fetal exposure in cesarean delivery; extends PK data but leaves open neonatal outcome confirmation.
Observational (n=6)
What is the disposition and placental transfer of bupivacaine after spinal anesthesia for cesarean section?
Bupivacaine administered via spinal anesthesia for cesarean section crosses the placenta but reaches the fetus in very low amounts.
Kuhnert et al. (1987) conducted an observational in Elective cesarean section (n=6). Bupivacaine via spinal anesthesia was evaluated on Uptake of bupivacaine from the subarachnoid space and its placental transfer. Bupivacaine administered via spinal anesthesia for cesarean section crosses the placenta in very low amounts, with mean maternal plasma levels of 59 ng/ml and umbilical venous levels of 20.2 ng/ml.
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