Why the study?
What are the plasma concentrations of bupivacaine in neonates receiving continuous epidural infusion?
Population
13 neonates who received lumbar epidural anesthesia during major abdominal surgery
Design
Case_series
Follow-up
48 hours
Authors
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Raises concern for accumulation during prolonged neonatal epidural use; hypothesis-generating for safety monitoring in prospective studies.
What are the plasma concentrations of bupivacaine in neonates receiving continuous epidural infusion?
Continuous epidural infusion of bupivacaine at 0.2 mg/kg/h in neonates appears safe up to 48 hours, but increasing total plasma concentrations raise concerns for longer infusions.
Larsson et al. (1997) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: