Why the study?
Does 10 ml of 0.125% bupivacaine reduce maternal and neonatal plasma concentrations compared to 7 ml of 0.375% bupivacaine in parturients receiving epidural analgesia?
Population
30 parturients receiving epidural analgesia for labor and vaginal delivery, and their newborns
Comparison
10 ml of 0.125% bupivacaine plus epinephrine… vs 7 ml of 0.375% bupivacaine plus epinephrine…
Design
Cohort
Follow-up
at delivery
Authors
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Lower-concentration bupivacaine was associated with reduced maternal/neonatal plasma levels; leaves open safety benefits pending randomized confirmation.
Does 10 ml of 0.125% bupivacaine reduce maternal and neonatal plasma concentrations compared to 7 ml of 0.375% bupivacaine in parturients receiving epidural analgesia?
A low concentration-low dose technique using 10 ml of 0.125% bupivacaine provides safer epidural analgesia with significantly lower maternal and neonatal plasma concentrations compared to 0.375% bupivacaine.
Zundert et al. (1987) studied this question.
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